' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.4
USERS' SCORE
Very Good
Based on 10 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Highly relevant to autoimmune research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
8
Vitamin D aids Graves' disease therapy
A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study.
Directly links vitamin D and TRAB
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Read More
8
Vitamin D linked to alopecia areata
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
Direct impact on autoimmune disorder
Our investigation focused on the role of vitamin D in the autoimmune disorder known as alopecia areata (AA). We delved into data from various studies, including a meta-analysis of 34 papers covering nearly 5,000 participants from multiple countries.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
Read More
Most Useful Reviews
8.8
Significant improvement
The quality is superb, as recommended by my doctor for health. I’m very pleased with its effects and look forward to ordering more.
Read More
8
No side effects
I’ve been taking vitamin D cholecalciferol for a month now, as my doctor identified a deficiency. I have experienced no side effects. They’re easy to take, and I store them in the fridge to prevent sticking. If you find this review helpful, please give it a thumbs up.
Read More
8.8
Reduced fatigue
After two weeks of taking vitamin D, I have noticed improvement in my fatigue and sleep quality, despite a deficiency. I would recommend this to friends.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 13 Researches
7.4
9.5
Vitamin D3 aids autoimmune thyroiditis
Supplementation with active vitamin D3 ameliorates experimental autoimmune thyroiditis in mice by modulating the differentiation and functionality of intrathyroidal T-cell subsets.
Highly relevant to autoimmune research
We observed that vitamin D3 supplementation may play a significant role in managing autoimmune thyroiditis, a condition often marked by thyroid inflammation. In this study, researchers induced autoimmune thyroiditis in female mice and administered vitamin D3 to evaluate its effects on the disease.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
After eight weeks of treatment, the results showed a notable reduction in thyroid damage and lower levels of thyroid autoantibodies in the mice receiving vitamin D3. Specifically, the vitamin appeared to inhibit the activity of certain inflammatory immune cells, which are typically elevated in autoimmune conditions. At the same time, it seemed to support the activity of regulatory immune cells that help keep inflammation in check.
This study highlights the potential of vitamin D3 as a therapeutic option to mitigate the effects of autoimmune thyroiditis, suggesting that it could help balance the immune response in affected individuals. As researchers continue to delve into the role of vitamin D in autoimmune disorders, findings like these support the notion that maintaining adequate vitamin D levels might be crucial for immune health.
Read More
8
Vitamin D aids Graves' disease therapy
A beneficial levels of 25-hydroxyvitamin D for a decrease in thyrotropin receptor antibody (TRAB) in patients with Graves' disease: a real-world study.
Directly links vitamin D and TRAB
We explored the connection between vitamin D levels and the management of Graves' disease, an autoimmune disorder characterized by overactive thyroid function. Through our research with 171 patients, we aimed to see if pre-treatment levels of 25-hydroxyvitamin D could influence the reduction of thyrotropin receptor antibodies (TRAB) during treatment.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Our study divided patients into three groups based on their vitamin D levels: less than 20 ng/mL, between 20-29 ng/mL, and 30 ng/mL or more. The findings were quite revealing. We observed that patients with vitamin D levels ranging from 20 to 29 ng/mL experienced significantly higher rates of TRAB remission and negative conversion compared to the other groups during follow-ups at 6, 12, and 24 months.
This suggests that maintaining vitamin D within this specific range can be beneficial for patients newly diagnosed with Graves' disease as they undergo antithyroid treatment. However, we noted that vitamin D levels did not seem to affect the normalization of free triiodothyronine and free thyroxine levels over time.
In summary, our findings emphasize the potential role of adequate vitamin D levels in supporting immune regulation and therapeutic outcomes in autoimmune disorders, particularly Graves' disease.
Read More
8
Calcitriol enhances MSCs in RA
Calcitriol Treated Mesenchymal Stem Cells Modulated Immune Response in Collagen-Induced Rheumatoid Arthritis in BALB/c Mice.
Relevant investigation of vitamin D
We investigated the effects of calcitriol, an active form of vitamin D, on mesenchymal stem cells (MSCs) in the context of rheumatoid arthritis (RA), a chronic inflammatory disease affecting joints. Using BALB/c mice, we induced RA with collagen and Freund's complete adjuvant and divided the mice into three groups: untreated, treated with untreated MSCs, and treated with calcitriol-exposed MSCs.
Our findings revealed that MSCs treated with calcitriol showcased enhanced regulatory functions, particularly regarding immune responses from splenocytes. This treatment also resulted in reduced inflammatory markers. Importantly, we observed how calcitriol modulated the production of certain cytokines, increasing levels of IL-4, IL-10, and TGF-β, while decreasing INF-γ and IL-17 compared to the positive control group.
Overall, this study highlights the potential of calcitriol treated MSCs in improving immune regulation, offering promising insights for future advanced therapies in autoimmune disorders like RA.
Our findings revealed that MSCs treated with calcitriol showcased enhanced regulatory functions, particularly regarding immune responses from splenocytes. This treatment also resulted in reduced inflammatory markers. Importantly, we observed how calcitriol modulated the production of certain cytokines, increasing levels of IL-4, IL-10, and TGF-β, while decreasing INF-γ and IL-17 compared to the positive control group.
Overall, this study highlights the potential of calcitriol treated MSCs in improving immune regulation, offering promising insights for future advanced therapies in autoimmune disorders like RA.
Read More
8
Vitamin D linked to alopecia areata
Association Between Serum Trace Elements Level and Alopecia Areata: A Systematic Review and Meta-Analysis.
Direct impact on autoimmune disorder
Our investigation focused on the role of vitamin D in the autoimmune disorder known as alopecia areata (AA). We delved into data from various studies, including a meta-analysis of 34 papers covering nearly 5,000 participants from multiple countries.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
The findings demonstrated a clear association between low vitamin D levels and increased risk of AA. Specifically, patients with alopecia areata exhibited significantly lower serum vitamin D levels compared to healthy individuals. In fact, those with vitamin D deficiency were found to be at a higher risk of developing the condition.
These results suggest that vitamin D supplementation could potentially serve as an effective treatment strategy for individuals suffering from AA. However, it’s important to note that while vitamin D showed promise, the study did not find significant differences in other trace elements, such as copper, in relation to AA.
Overall, our research underscores the importance of maintaining adequate vitamin D levels, as it may play a crucial role in the management of autoimmune disorders like alopecia areata.
Read More
8
Vitamin D’s therapeutic potential in RA
The role of vitamins D, B12, C, and K in modulating inflammation and disease management in rheumatoid arthritis: a comprehensive review.
Focus on vitamin D efficacy
We explored the significant role of vitamin D in managing rheumatoid arthritis (RA), a chronic autoimmune disorder characterized by joint inflammation and damage. The evidence points to a common deficiency in vitamin D among RA patients, which can be linked to increased severity of the disease.
Our observations suggest that vitamin D may help modulate the immune response and reduce inflammation. There has been promising data showing that vitamin D supplementation can lead to improvements in disease activity, as well as a decrease in inflammatory markers among patients.
In addition to its immune-boosting properties, we recognized that managing vitamin D levels might also alleviate some of the symptoms associated with RA, such as fatigue, which can be exacerbated by deficiencies. Overall, the compelling findings underline the potential benefits of vitamin D as a therapeutic option for patients dealing with autoimmune disorders like RA.
Our observations suggest that vitamin D may help modulate the immune response and reduce inflammation. There has been promising data showing that vitamin D supplementation can lead to improvements in disease activity, as well as a decrease in inflammatory markers among patients.
In addition to its immune-boosting properties, we recognized that managing vitamin D levels might also alleviate some of the symptoms associated with RA, such as fatigue, which can be exacerbated by deficiencies. Overall, the compelling findings underline the potential benefits of vitamin D as a therapeutic option for patients dealing with autoimmune disorders like RA.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 10 Reviews
8.5
9.5
Effective treatment
I take vitamin D at 2,000 IU daily or 5,000 every other day. I know friends who raised their levels to normal, indicating that all leading brands, including this one, can effectively treat vitamin D deficiency.
9.5
Perfect for needs
My doctor prescribed 10,000 IU daily due to a severe vitamin D deficiency that sunlight alone couldn’t resolve. Unlike my previous supplement with soybean oil, this one uses olive oil, which is perfect for my autoimmune disorder.
9.5
Improved immune system
I’m thrilled with these vitamins! Delivery was quick, and after a month, my health has greatly improved. The capsules are easy to swallow, with no taste. I feel my immune system has strengthened significantly.
8.8
Significant improvement
The quality is superb, as recommended by my doctor for health. I’m very pleased with its effects and look forward to ordering more.
8.8
Stable vitamin D levels
I've been taking this vitamin D, and after a month, I raised my blood levels from 26 to 43 with the dosage of 10,000 IU. My husband takes 5,000 IU daily without issues. I recommend continuing to support vitamin D levels, as they can drop rapidly without proper intake.
